Dehydro-Tocotrienol-? Counteracts Oxidative-Stress-Induced Diabetes Complications in db/db Mice

Hyperglycemia, hyperlipidemia, and adiposity are the main factors that cause inflammation in type 2 diabetes due to excessive ROS production, leading late complications. To counteract effects of increased free radical we searched for a compound with effective antioxidant properties can induce coenzyme Q biosynthesis without affecting normal cellular functions. Tocotrienols members vitamin E family, well-known as efficient antioxidants more than tocopherols. Deh-T3? is modified form naturally occurring tocotrienol-?. The synthesis this involves sequential modification geranylgeraniol. In study, investigated different experimental models was found possess multifaceted capacities. addition enhanced wound healing, deh-T3? improved kidney liver functions, reduced steatosis, heart recovery after ischemia insulin sensitivity adipose tissue mice model diabetes. exerts these positive several organs diabetic reducing non-fasting blood glucose levels, suggesting both its improvement mitochondrial function involved, which central